University Circle

cle clinic researchers discover protein linked to obesity, diabetes
Researcher J. Mark Brown and his team at the Cleveland Clinic Lerner Research Institute have discovered a protein that might promote obesity and diabetes. Therefore, blocking that protein, called ABHD6, might prevent these diseases.

ABHD6 regulates the brain’s endocannabinoid system, which is involved in metabolism, cravings and hunger.
 
Brown discovered ABHD6’s role in fat storage while studying a mutation in a different protein in the same group, ABHD5. “Normally, fat is stored in triglyceride tissue,” Brown explains. “With abnormal ABHD5, fat is stored in every other cell in the body. In studying that we discovered a crucial breakdown in ABHD6 and we decided to study it.”
 
Brown conducted a study in mice to see how fat was stored in ABHD6, to see if it impacted type-2 diabetes, obesity and fatty liver disease. He found that blocking the protein’s function had a direct impact on these diseases.
 
The research indicates that blocking function of ABHD6 in mice protects against all diseases driven by eating a high-fat diet. Further research could actually lead to a pill that would block ABHD6, and therefore prevent obesity.
 
Brown’s findings were published last week in the journal Cell Reports. “Our paper will be the first that shows the importance of the enzyme in regulating the way the body stores fat,” explains Brown, who has spent the past four years researching ABHD6.
 
“It’s hard to say if it would ever end up being a magic pill to cure obesity,” says Brown. “We look at it like a preventative measure. We’re really excited to move forward with it and conduct safety trials with humans. We know it works in mice, so it’s very important to translate our findings into human studies as quickly as we can.”

 
Source: J. Mark Brown
Writer: Karin Connelly
ny post explores the local scene, lauds city's 'revival'
In a New York Post feature titled “Cleveland is Seeing a Revival,” writer Jennifer Ceasar explores some of Cleveland’s attractions, which increasingly are garnering attention outside of Northeast Ohio.
 
“If you were an Ohioan back in the early ’80s, you might remember 'New York’s the Big Apple, but Cleveland’s a Plum,' an ad campaign to rebrand the failing Rust Belt town. Though it never stuck, today’s Cleveland is earning laurels for its homegrown talent, like Iron Chef Michael Symon, along with farm-to-table eateries, award-winning craft breweries and cool art spaces.”
 
Some of the writer's many stops included Ohio City, home of Flying Fig, Great Lakes Brewing Company and the Transformer Station, Tremont, which houses some of the city’s best eateries, and University Circle, where many of Cleveland’s top cultural attractions reside.
 
Check out the full piece here.

huffpo praises efforts by cle orchestra to attract young audience
In a Huffington Post article titled "In Tune With the Next Generation," Jesse Rosen, president of the League of American Orchestras, praises the Cleveland Orchestra's efforts to be the band with the youngest audience.
 
"The Cleveland Orchestra, best known as one of the world's finest orchestras, with an equally outstanding hall and decades of extraordinary musical leadership, now has a new goal: to be the orchestra with the youngest audience. An audacious goal, but by the looks of the audience in Severance Hall last Friday night at the concert I heard, they are well on their way," he writes.
 
"The performance I heard in Cleveland was one of a three-concert set on their opening weekend. The uncompromising programs included works by Mahler, Beethoven and Schumann. Twenty seven percent of the audience at those three concerts were young people. You read that right, 27 percent. I am one year shy of enjoying senior discounts and I can tell you that concerts, like many things, are more fun with young people around. The vibe in the hall was fantastic."
 
Read the rest of the feature here.
art mag covers first cma exhibit at transformer
A feature in the arts-based blog ArtDaily covers at length the latest exhibit at the new Transformer Station in Ohio City, which is the first for co-curator Cleveland Museum of Art.
 
"The Cleveland Museum of Art presents The Unicorn, its debut exhibition at Transformer Station, a new contemporary art venue owned by the Bidwell Foundation on Cleveland's west side. The Unicorn refers to the book of the same title by Martin Walser, an author whose work often questions how humans continually reshape the past."
 
The group exhibition includes the work of five internationally renowned contemporary artists: Neïl Beloufa, Martin Soto Climent, Shana Lutker, Haris Epaminonda and Daniel Gustav Cramer. The work, some created specifically for this exhibition, explore how memory is constructed by individuals looking backwards from a constantly shifting point.
 
Read the rest right here.

novelmed's macular degeneration therapy ready for clinical trials
NovelMed Therapeutics, a biotech company founded in 2003 that develops treatments for macular degeneration, announced that it has developed an antibody compound that is effective in treating wet age-related macular degeneration (AMD) and possibly the dry form of the disease as well. AMD affects more than two million people in the United States and is a leading cause of blindness among adults.

Two independent pre-clinical investigations showed that NovelMed's lead compound, an alternative pathway inhibitor, prevents wet-AMD. “We believe our technology inhibits the progression of AMD,” says Rekha Bansal, CEO and founder of NovelMed. “The animal data supports treatment for wet AMD. The compound could possibly treat the dry form as well, which accounts for 90 percent of the AMD market.”
 
Bansal says the therapy currently is in the manufacturing phase, with safety studies scheduled to begin next year and human clinical trials to start in late 2014.
 
“I think we are at the forefront in time with the potential to treat both wet and dry AMD,” says Bansal. “It’s the first treatment of its kind.”
 
Bansal is proud that this breakthrough is happening in Northeast Ohio. “This is a drug coming out of Cleveland for vision loss,” she says. “It’s going to be a great thing for Cleveland.”
 
NovelMed currently has four R&D positions open due to its recent growth.

 
Source: Rekha Bansal
Writer: Karin Connelly
the cutting edge: three cleveland medical innovations bound for great things
Modern medicine is constantly innovating ways to improve the length and quality of human life. Cleveland researchers are leading the way with cutting-edge treatments and technologies that can blast a brain tumor with a laser, detect a concussion using an iPad, and test for prostate cancer by way of genetics.
noaca director touts bikes, multi-modal transportation in annual address
Speaking last week at the annual meeting of the Northeast Ohio Areawide Coordinating Agency (NOACA), the regional transportation planning agency for Northeast Ohio, Executive Director Grace Gallucci promised a more strategic distribution of money for projects and greater emphasis on multi-modal transportation options.

"We want more choices; that's what freedom -- being an American -- is about," she said. "NOACA is not trying to vilify the automobile; we're trying to attract the best and the brightest. Bicycling is increasingly popular, and more communities are integrating bike plans. Americans are driving less for the first time in a generation, and that trend is clearly led by the Millenial generation."

NOACA also has launched a far-reaching plan to assemble information on the condition of every highway, road and street in five counties, and use this information to make objective decisions about transportation spending. "Making decisions in an objective, data-driven way is more important now than ever. If there ever was a time to make decisions make economic sense, the time is now."

Gallucci touted NOACA's new Regional Bicycle Transportation Plan, a $15 million investment in the City of Cleveland's W. 73rd Street Extension Project and the Clifton Boulevard streetscape project among NOACA's recent, big ticket investments.

Peter Rogoff, Federal Transit Administrator, gave the keynote address. He argued that transit-oriented development projects can spark urban revitalization if done right, citing Cleveland's bus-rapid transit along the Euclid Corridor as one example of success.

Cleveland is a "national model for doing" with the Euclid Corridor project, Rogoff stated, because the project cost a lot less than light rail but resulted in big ridership gains and major economic development along the corridor. Other cities are studying how Cleveland did it and replicating our success, he added.


Source: Grace Gallucci, Peter Rogoff
Writer: Lee Chilcote
ny post promotes pair of cleveland art museums
In a New York Post feature titled “Hit up Ohio’s many art museums,” writer Jennifer Caesar highlights the wealth of masterpieces one can enjoy in the great state of Ohio, including those exhibited by The Cleveland Museum of Art (CMA) and MOCA Cleveland.
 
"Ohio and the arts are not such strange bedfellows: Flush with cash in the early 20th century -- from industries like steel, rubber and soap -- Cleveland, Toledo, Akron and Cincinnati built grand museums, and acquired masterpieces to fill them."
Highlighted at CMA is the "stellar Islamic art, fine European paintings (JMW Turner, Van Gogh, Monet and Picasso among them) and excellent contemporary pieces by the likes of Christo, Gerhard Richter and Chuck Close."
 
Over at MOCA is, "a rotating series of cutting-edge contemporary art exhibitions (the museum does not have a permanent collection), which lean heavily toward video and performance art."
 
Check out the full story here.

techpint event touches on lessons learned from business failures
"Failure" is a tough word, particularly for entrepreneurial types throwing so much of their lives into a venture that might go belly up within a few months. However, Paul McAvinchey, creator of TechPint, believes valuable lessons can be learned from disappointment.

Such is the theme of this fall's TechPint conference, a casual gathering for entrepreneurs and investors in Internet technology. Coordinator McAvinchey expects more than 250 of the region's most innovative tech pacesetters to attend the quarterly-held event taking place tonight (September 26) at Sterle’s Slovenian Country House. Speakers John Gadd of Hotcards.com, Kendall Wouters of Reach Ventures and Phil Brennan of Echogen Power Systems will touch on how businesses can bounce back from seemingly crushing setbacks.

"It's a fact that you must fail many times before you see success," says McAvinchey, who moved to Cleveland from County Tipperary, Ireland, in April 2012 to lead product innovation for MedCity Media. "If you're failing, that means you're trying. That's a good thing."

Even stories of tremendous achievement, like the billion-dollar acquisition of Instagram, began on a rocky road of risk and false starts, McAvinchey points out.

"Failure will work for you if you learn from it," he says.

The informal get-together is designed to connect the region's tech thinkers over a couple pints of beers, says McAvinchey. TechPint's moniker this month is "Techtoberfest," in appreciation of this suds-filled season of the year.

Autumn also is a time for scary stories, and attendees will hear a few frightening business-related tales at TechPint. "It's important to celebrate failure," McAvinchey says. "This is a way to bring positive attention to it."

 
SOURCE: Paul McAvinchey 
WRITER: Douglas J. Guth
thriving startup community means jobs aplenty... for the right candidates
The large number of open jobs in the startup community indicates these companies are doing well and growing. But working for a young startup has unique challenges. Recruiters and employers discuss some of the critical qualities required for those looking for a good fit with a startup.
men's journal drops into cleveland for a visit
In a Men's Journal travel feature titled "Visiting Cleveland, on Purpose," writer Robert Reid manages to enjoy himself during an action-packed visit to town -- and also manages to trot out a few hackneyed affronts as well.
 
"Spread out on the south shore of Lake Erie, 'The Forest City' -- called the 'mistake by the lake' by the sort of people who talk like that -- is a pleasant surprise for visitors who actually make the trip," Reid writes. "Just the names of the neighborhoods, including Slavic Village, Little Italy, and Asiatown, are a tribute to the city’s melting-pot roots, which manifest in great fusion cuisine."

In the piece, Reid mentions Happy Dog, Beachland Ballroom, the Orchestra, Big Fun, MOCA, Melt and others.
 
Read the rest of the (back-handed) compliment here.

ny times gives ink to new rust belt mag 'belt'
In a New York Times Arts Beat post titled “New Magazine Celebrates ‘Rust Belt Chic,’ With a Wink,” writer Jennifer Schuessler details her conversation with Belt magazine editor Anne Trubek about a new publication dedicated to fostering a new journalistic beat in Cleveland.
 
"The decaying cities of the post-industrial Midwest can sometimes seem like a museum of things America used to make: cars, refrigerators, steel, televisions. But if a start-up in Cleveland gets its way, the region may help rebuild the market for another endangered product -- long-form magazine journalism," Schuessler writes.
The magazine offers up a collection of essays and reporting that seeks to explore the regional identity that is known as the Rust Belt.
 
“I cringe at words like ‘authentic,’” Trubek says in the article. “But the rust belt aesthetic isn’t about the ephemeral global economy, it’s about boots on the ground and things hidden in grandma’s attic. We want to explore that.”
 
Check out the full interview here.

cleveland clinic innovations launched spinoff company to create breast cancer vaccine
Cleveland Clinic Innovations has launched a spinoff company, Shield Biotech, out of the Lerner Research Institute. Led by Vincent Tuohy, the company is developing a vaccine for breast cancer.

The vaccine uses the body’s own immune system to fight off and kill cancerous tumors. Tuohy, who serves as Shield’s chief science officer, has been working on this theory for the past 11 years. 
 
The next step is to secure FDA approval for human clinical trials, probably within the next two years. Researchers found that a single vaccination could prevent breast tumors from occurring in mice genetically bred to develop breast cancer, while also inhibiting the growth of already existing breast tumors. The research was originally published in Nature Medicine in 2010.
 
“It works in animals,” says Tuohy. “It’s safe and very effective. We’d like to see women live longer without tumors, not women live longer with tumors.”
 
Tuohy sees the vaccine as particularly effective in breast cancers that are aggressive and tend to recur. “Triple-negative breast cancer has a higher recurrence rate than other forms of breast cancer and is insensitive to current forms of adjuvant therapy,” he says. “It’s the predominant form of breast cancer that occurs, for example, in women with BRCA1 mutations. “
 
Tuohy sees potential in eventually immunizing against prostrate and ovarian cancers as well. 

Source: Vincent Tuohy
Writer: Karin Connelly
bowling with strangers: emerging patterns of desegregation foretell a vibrant economy
Cleveland, like most American cities, has had its challenges regarding segregation. But emerging patterns of desegregation can significantly advance our city's position as a center of innovation. This represents a key opportunity to reconstitute a new American neighborhood model by harnessing the potential of diversification.
rta healthline praised for cost/benefit ratio in forbes
In a Forbes feature titled “Bus Rapid Transit Spurs Development Better Than Light Rail or Streetcars: Study,” contributor Jeff McMahon writes of an upcoming report by the Institute for Transportation and Development Policy that explores the cost/benefit ratio of various types of urban transportation.
 
“For example, Cleveland’s Healthline, a BRT project completed on Cleveland’s Euclid Avenue in 2008, has generated $5.8 billion in development -- $114 for each transit dollar invested. Portland’s Blue Line, a light rail project completed in 1986, generated $3.74 per dollar invested.”
 
The report goes on to discuss the many variables going into the study and its relation to the urban environment.
 
Read the full piece here.

modern-day home ec school agrarian collective teaches the 'hows of the home'
Kelli Hanley Potts has lived in Denver and Albuquerque, where she got involved in the slow food movement, replaced her front lawn with a vegetable garden, and worked for some of those cities' top chefs. When she got the urge to move back home to Cleveland, she knew she wanted to do something food-related.

That's when she stumbled upon a business idea. Despite the rise of the local food movement, most people had no idea how to cook kale, make jam or preserve food. She asked 18 female friends if they knew how to make a pie from scratch, and only two said yes.

Additionally, many people in the local farming movement have trouble explaining and marketing their products to customers, who are largely unfamiliar with them, she explains.

There are no cooking schools in Cleveland that did what she wanted to do -- connect people back to the land and back to their grandmothers' kitchens by teaching them the age-old skills of home economics -- so she decided to create one.

"I didn't want to watch a chef in front of me and drink wine," says Hanley Potts. "I wanted to learn something. I wanted to reconnect people to the lineage of the table, help them build their own table culture."

She recently launched the Agrarian Collective, an earth-to-table lifestyle school. Her mobile cooking school is offering classes this fall that cover topics like roasting your own coffee, fermented and cultured foods, and discovering local apples, among others. She'll be teaching students how to make the perfect pesto at this weekend's Cleveland Flea.

She was aided by a $5,000 low-interest loan from Bad Girl Ventures, which enabled her to purchase supplies and begin reaching out to chefs and farmers as partners.

"This is like home ec, but not quite as official and nerdy," she says. "It's about reconnecting people. All these things we once learned and were taught, they're missing. We're teaching people the 'how' of home."

Source: Kelli Hanley Potts
Writer: Lee Chilcote
halfway there: sustainable cleveland environmental initiative making progress, says city official
Are you sustainable, Cleveland? That's the question environmentally conscious city officials are asking heading into the fifth annual Sustainable Cleveland 2019 Summit. The initiative to build "a green city on a blue lake" is at the halfway mark, and Cleveland's new chief of sustainability believes Northeast Ohio is meeting the metrics set out a half decade ago.
travel writer swoons over cleveland visit
In a Huffington Post travel feature titled "The American Grandeur of Cleveland," contributor Sally Fay was so smitten by our city that she writes, "There are many reasons to visit Cleveland, enough to swing the vote right into moving there!"
 
She writes that "Cleveland has a character that appreciates its past while embracing the renewal of the future. In 2013, the city has a different kind of American grandeur than it did in its industrial heyday of the early 20th century, but rather than get stuck in the past and not learn the lessons from it, Cleveland has aged well into a modern, global and down-to-earth city."
 
Stops on her exhaustive visit through town included Lake View Cemetery, Cleveland Cultural Gardens, Cleveland Art Museum, Severance Hall, Museum of Contemporary Art, Cleveland Institute of Music, Rock and Roll Hall of Fame, PlayhouseSquare, West Side Market and many other stops.
 
She closes out the piece with this resounding endorsement:
 
"If you are looking for opportunities, reasonably priced real estate, cultural diversity, high culture, top medicine, professional sports and mid-western charm, pack your bags and discover the American grandeur and quality of life of Cleveland has going for it!"
 
Read the rest right here.

summer festival slideshow
As summer transitions into fall, we wanted to take a moment to look back on a season filled with family, friends and festive neighborhood gatherings. Throughout it all, Fresh Water photographer Bob Perkoski has been attending and shooting the best summer festivals. This slideshow features captured images from a dozen events.
clinic's cosgrove aims to improve health of residents and city
In a lengthy Forbes feature titled "City Surgeon: Can The Cleveland Clinic Save Its Hometown?" writer Matthew Herper reports on Delos “Toby” Cosgrove's tenure at the Cleveland Clinic and his efforts to leverage healthcare to improve the Clinic's neighborhood and the region's economy.
 
"The rough old neighborhood is a distant memory, replaced by a gleaming testament to modern medicine stretching out over 46 buildings and covering 167 acres. Protected by a dedicated 141-trooper force of state police, there is a conference center, a fancy hotel and a farmers’ market. Over Cosgrove’s tenure the clinic’s revenues have nearly doubled to $6.2 billion."
 
But Cosgrove's biggest brainstorm was to build a "giant mall for hospital buyers." 
 
"Think about the things that go into a hospital. Shades, televisions, chairs, tables, wall coverings, all the medical gear, the operating tables, you name it,” Cosgrove is quoted in the piece.
 
"What is emerging is an Epcot Center for med tech. GE Healthcare, Siemens, Philips Health Care and Cardinal Health are among the 22 confirmed tenants in the soon-to-be-completed center. Next door, Bennett has already booked conventions that will bring 89,395 attendees this year and 100,400 next. By the end of 2016, he says, bookings should be enough to pay back the $465 million it took to construct both buildings."
 
“It will begin to influence the city as it comes back and make it a destination medical city,” Cosgrove predicts.
 
Read the rest of the article here.