Health + Wellness
Researcher J. Mark Brown and his team at the Cleveland Clinic Lerner Research Institute have discovered a protein that might promote obesity and diabetes. Therefore, blocking that protein, called ABHD6, might prevent these diseases.
ABHD6 regulates the brain’s endocannabinoid system, which is involved in metabolism, cravings and hunger.
Brown discovered ABHD6’s role in fat storage while studying a mutation in a different protein in the same group, ABHD5. “Normally, fat is stored in triglyceride tissue,” Brown explains. “With abnormal ABHD5, fat is stored in every other cell in the body. In studying that we discovered a crucial breakdown in ABHD6 and we decided to study it.”
Brown conducted a study in mice to see how fat was stored in ABHD6, to see if it impacted type-2 diabetes, obesity and fatty liver disease. He found that blocking the protein’s function had a direct impact on these diseases.
The research indicates that blocking function of ABHD6 in mice protects against all diseases driven by eating a high-fat diet. Further research could actually lead to a pill that would block ABHD6, and therefore prevent obesity.
Brown’s findings were published last week in the journal Cell Reports. “Our paper will be the first that shows the importance of the enzyme in regulating the way the body stores fat,” explains Brown, who has spent the past four years researching ABHD6.
“It’s hard to say if it would ever end up being a magic pill to cure obesity,” says Brown. “We look at it like a preventative measure. We’re really excited to move forward with it and conduct safety trials with humans. We know it works in mice, so it’s very important to translate our findings into human studies as quickly as we can.”
Source: J. Mark Brown
Writer: Karin Connelly
ABHD6 regulates the brain’s endocannabinoid system, which is involved in metabolism, cravings and hunger.
Brown discovered ABHD6’s role in fat storage while studying a mutation in a different protein in the same group, ABHD5. “Normally, fat is stored in triglyceride tissue,” Brown explains. “With abnormal ABHD5, fat is stored in every other cell in the body. In studying that we discovered a crucial breakdown in ABHD6 and we decided to study it.”
Brown conducted a study in mice to see how fat was stored in ABHD6, to see if it impacted type-2 diabetes, obesity and fatty liver disease. He found that blocking the protein’s function had a direct impact on these diseases.
The research indicates that blocking function of ABHD6 in mice protects against all diseases driven by eating a high-fat diet. Further research could actually lead to a pill that would block ABHD6, and therefore prevent obesity.
Brown’s findings were published last week in the journal Cell Reports. “Our paper will be the first that shows the importance of the enzyme in regulating the way the body stores fat,” explains Brown, who has spent the past four years researching ABHD6.
“It’s hard to say if it would ever end up being a magic pill to cure obesity,” says Brown. “We look at it like a preventative measure. We’re really excited to move forward with it and conduct safety trials with humans. We know it works in mice, so it’s very important to translate our findings into human studies as quickly as we can.”
Source: J. Mark Brown
Writer: Karin Connelly
The City of Euclid recently completed Phase I of its ambitious Waterfront Improvements Plan, creating an expanded fishing pier, a new multi-purpose trail and an accessible switchback ramp to the lakefront.
Euclid Mayor Bill Cervenik says the $1.7 million project is part of a larger, $30 million push to expand Euclid's waterfront with a new, three-quarter mile beachfront and marina that he hopes will become a regional draw.
"We want to re-establish the historic beaches along the shoreline and make sure they're accessible, as Cleveland and the Metroparks are trying to do," he says.
Phase I of the waterfront plan was funded by $1.4 million from the City of Euclid and $355,000 from the State of Ohio. The city will seek additional aid to support future phases of the plan. "We'll be stopped dead in our tracks if we don't have assistance from the federal, state and county governments," Cervenik says.
Euclid now owns the majority of the three-quarter mile stretch of lakefront thanks to a donation from the K&D Group, a large apartment developer that owns lakefront property.
Over the long-term, Cervenik envisions a paved multi-purpose path along the entire stretch of cobble beach, which would include restored natural habitat. He also envisions sailing and kayak lessons and boating at the new marina once built.
For now, Euclid residents and visitors can enjoy the revitalized Sims Park, which Cervenik says complements nearly $14 million of recent development downtown.
Source: Bill Cervenik
Writer: Lee Chilcote
Euclid Mayor Bill Cervenik says the $1.7 million project is part of a larger, $30 million push to expand Euclid's waterfront with a new, three-quarter mile beachfront and marina that he hopes will become a regional draw.
"We want to re-establish the historic beaches along the shoreline and make sure they're accessible, as Cleveland and the Metroparks are trying to do," he says.
Phase I of the waterfront plan was funded by $1.4 million from the City of Euclid and $355,000 from the State of Ohio. The city will seek additional aid to support future phases of the plan. "We'll be stopped dead in our tracks if we don't have assistance from the federal, state and county governments," Cervenik says.
Euclid now owns the majority of the three-quarter mile stretch of lakefront thanks to a donation from the K&D Group, a large apartment developer that owns lakefront property.
Over the long-term, Cervenik envisions a paved multi-purpose path along the entire stretch of cobble beach, which would include restored natural habitat. He also envisions sailing and kayak lessons and boating at the new marina once built.
For now, Euclid residents and visitors can enjoy the revitalized Sims Park, which Cervenik says complements nearly $14 million of recent development downtown.
Source: Bill Cervenik
Writer: Lee Chilcote
NovelMed Therapeutics, a biotech company founded in 2003 that develops treatments for macular degeneration, announced that it has developed an antibody compound that is effective in treating wet age-related macular degeneration (AMD) and possibly the dry form of the disease as well. AMD affects more than two million people in the United States and is a leading cause of blindness among adults.
Two independent pre-clinical investigations showed that NovelMed's lead compound, an alternative pathway inhibitor, prevents wet-AMD. “We believe our technology inhibits the progression of AMD,” says Rekha Bansal, CEO and founder of NovelMed. “The animal data supports treatment for wet AMD. The compound could possibly treat the dry form as well, which accounts for 90 percent of the AMD market.”
Bansal says the therapy currently is in the manufacturing phase, with safety studies scheduled to begin next year and human clinical trials to start in late 2014.
“I think we are at the forefront in time with the potential to treat both wet and dry AMD,” says Bansal. “It’s the first treatment of its kind.”
Bansal is proud that this breakthrough is happening in Northeast Ohio. “This is a drug coming out of Cleveland for vision loss,” she says. “It’s going to be a great thing for Cleveland.”
NovelMed currently has four R&D positions open due to its recent growth.
Source: Rekha Bansal
Writer: Karin Connelly
Two independent pre-clinical investigations showed that NovelMed's lead compound, an alternative pathway inhibitor, prevents wet-AMD. “We believe our technology inhibits the progression of AMD,” says Rekha Bansal, CEO and founder of NovelMed. “The animal data supports treatment for wet AMD. The compound could possibly treat the dry form as well, which accounts for 90 percent of the AMD market.”
Bansal says the therapy currently is in the manufacturing phase, with safety studies scheduled to begin next year and human clinical trials to start in late 2014.
“I think we are at the forefront in time with the potential to treat both wet and dry AMD,” says Bansal. “It’s the first treatment of its kind.”
Bansal is proud that this breakthrough is happening in Northeast Ohio. “This is a drug coming out of Cleveland for vision loss,” she says. “It’s going to be a great thing for Cleveland.”
NovelMed currently has four R&D positions open due to its recent growth.
Source: Rekha Bansal
Writer: Karin Connelly
Modern medicine is constantly innovating ways to improve the length and quality of human life. Cleveland researchers are leading the way with cutting-edge treatments and technologies that can blast a brain tumor with a laser, detect a concussion using an iPad, and test for prostate cancer by way of genetics.
Cleveland's economic leaders have worked hard to parade the city as a hub for innovation. A chance to further show off Northeast Ohio's entrepreneurial acumen is a driving force behind Shaker Heights accelerator LaunchHouse's sponsorship of Cleveland Entrepreneurship Week (Cleveland EW), an upcoming four-day celebration of business success.
The event, scheduled for November 4-8, was created to give entrepreneurs and investors the knowledge and resources to grow the Northeast Ohio business community, says LaunchHouse co-founder Todd Goldstein.
LaunchHouse will kick off Cleveland EW at its Shaker Heights headquarters by presenting the 11 technology startups participating in its Accelerator Program. The rest of the week will feature speakers and other events that give entrepreneurs from all over the country an opportunity to connect with potential financial backers as well as fellow businesspeople.
"We're giving them exposure to people they normally wouldn't meet," says Goldstein. "Meeting the right person can help turn a small business into a large business."
LaunchHouse pushing for the entrepreneurship event aligns with its mission of local job creation through seed capital, education and innovation, notes Goldstein. With Cleveland striving to be on the forefront of the new economy, an event like Cleveland EW can put the area in a positive national spotlight.
"We've worked to change how Northeast Ohio is viewed in terms of entrepreneurship," Goldstein says. "This [event] is about showcasing the region as a place of innovation and capital formation."
SOURCE: Todd Goldstein
WRITER: Douglas J. Guth
The event, scheduled for November 4-8, was created to give entrepreneurs and investors the knowledge and resources to grow the Northeast Ohio business community, says LaunchHouse co-founder Todd Goldstein.
LaunchHouse will kick off Cleveland EW at its Shaker Heights headquarters by presenting the 11 technology startups participating in its Accelerator Program. The rest of the week will feature speakers and other events that give entrepreneurs from all over the country an opportunity to connect with potential financial backers as well as fellow businesspeople.
"We're giving them exposure to people they normally wouldn't meet," says Goldstein. "Meeting the right person can help turn a small business into a large business."
LaunchHouse pushing for the entrepreneurship event aligns with its mission of local job creation through seed capital, education and innovation, notes Goldstein. With Cleveland striving to be on the forefront of the new economy, an event like Cleveland EW can put the area in a positive national spotlight.
"We've worked to change how Northeast Ohio is viewed in terms of entrepreneurship," Goldstein says. "This [event] is about showcasing the region as a place of innovation and capital formation."
SOURCE: Todd Goldstein
WRITER: Douglas J. Guth
Ninety two percent of residents in the Central neighborhood live below 200 percent of the poverty line, qualifying them to receive food from food pantries. Yet until recently, the future of the city's largest food pantry -- and the second-largest food pantry in Cuyahoga County -- was seriously in doubt.
Recently, the Society of St. Vincent de Paul of Cleveland (SVDP) stepped in to assume management of Brother Hubbard's Cupboard in the Carl Stokes Building at 6001 Woodland Avenue, which serves 1,700 people per month and over 20,000 annually.
"The need is still going up based on the number of people we're serving at food pantries, and the working poor tend to be the last ones affected by an economic upswing in a positive way," says John Litten, Executive Director of SVDP. "Northeast Ohio has been slower to recover than we've been led to believe."
The pantry previously was managed by the Capuchin Franciscan Brothers under the direction of Brother Walt Robb, but was in danger of closing when it was announced that Robb was leaving for another assignment.
Litten says SVDP has risen to the task of managing a massive food pantry that requires almost daily deliveries from the Cleveland Food Bank. Yet he stresses that it's about a lot more than just giving out food. "It's the human side that really gets to our mission, the person-to-person service," he says. "For many people, this may be the only person who's helping you today, smiling at you, asking how you're doing."
Although word is still getting out about the newly renamed SVDP Woodland Pantry, Litten says it's already making a difference. "The impact on the neighborhood is huge."
Source: John Litten
Writer: Lee Chilcote
Recently, the Society of St. Vincent de Paul of Cleveland (SVDP) stepped in to assume management of Brother Hubbard's Cupboard in the Carl Stokes Building at 6001 Woodland Avenue, which serves 1,700 people per month and over 20,000 annually.
"The need is still going up based on the number of people we're serving at food pantries, and the working poor tend to be the last ones affected by an economic upswing in a positive way," says John Litten, Executive Director of SVDP. "Northeast Ohio has been slower to recover than we've been led to believe."
The pantry previously was managed by the Capuchin Franciscan Brothers under the direction of Brother Walt Robb, but was in danger of closing when it was announced that Robb was leaving for another assignment.
Litten says SVDP has risen to the task of managing a massive food pantry that requires almost daily deliveries from the Cleveland Food Bank. Yet he stresses that it's about a lot more than just giving out food. "It's the human side that really gets to our mission, the person-to-person service," he says. "For many people, this may be the only person who's helping you today, smiling at you, asking how you're doing."
Although word is still getting out about the newly renamed SVDP Woodland Pantry, Litten says it's already making a difference. "The impact on the neighborhood is huge."
Source: John Litten
Writer: Lee Chilcote
ny times gives ink to new rust belt mag 'belt'
In a New York Times Arts Beat post titled “New Magazine Celebrates ‘Rust Belt Chic,’ With a Wink,” writer Jennifer Schuessler details her conversation with Belt magazine editor Anne Trubek about a new publication dedicated to fostering a new journalistic beat in Cleveland.
"The decaying cities of the post-industrial Midwest can sometimes seem like a museum of things America used to make: cars, refrigerators, steel, televisions. But if a start-up in Cleveland gets its way, the region may help rebuild the market for another endangered product -- long-form magazine journalism," Schuessler writes.
The magazine offers up a collection of essays and reporting that seeks to explore the regional identity that is known as the Rust Belt.
“I cringe at words like ‘authentic,’” Trubek says in the article. “But the rust belt aesthetic isn’t about the ephemeral global economy, it’s about boots on the ground and things hidden in grandma’s attic. We want to explore that.”
Check out the full interview here.
"The decaying cities of the post-industrial Midwest can sometimes seem like a museum of things America used to make: cars, refrigerators, steel, televisions. But if a start-up in Cleveland gets its way, the region may help rebuild the market for another endangered product -- long-form magazine journalism," Schuessler writes.
The magazine offers up a collection of essays and reporting that seeks to explore the regional identity that is known as the Rust Belt.
“I cringe at words like ‘authentic,’” Trubek says in the article. “But the rust belt aesthetic isn’t about the ephemeral global economy, it’s about boots on the ground and things hidden in grandma’s attic. We want to explore that.”
Check out the full interview here.
Core and shell renovations of the 150,000-square-foot Victory Center, a $26 million project located along the Health-Tech Corridor, are almost complete. Tenant build-outs will follow, and although none have signed leases yet, developer Scott Garson says that will change as his team finishes the common spaces and shows the property to more prospective tenants.
"Everybody thinks it's wonderful, great… The trick is getting the first one in," he says. "I have enough letters of intent out there that I'm confident it's only a matter of time."
Garson says the demand is there for flexible, ready-to-grow office space geared towards biomedical, research and technology companies, which is why he decided to undertake the project. He points out that nearby buildings owned by Geis Companies and Cumberland Development are almost completely full.
So far, Garson has completed the project without a bank loan, using partner equity and a $720,000 loan from the city, $2.5 million in tax increment financing, federal and state historic tax credits, and a $1 million State of Ohio job ready sites grant. Garson expects to secure bank financing in the near future for tenant build-outs.
The building's unique features include a new interior with a historic waffle slab ceiling, window wells that allow plenty of natural light, copious backup power, fiber-optic connectivity, and the right mechanicals in place for laboratory space. The building will be certified LEED Silver, saving tenants 20 percent on utility costs. Finally, it has views of downtown, free parking and HealthLine access.
"We went through a recycling program with the materials and our landscaping uses stormwater management strategies," says Michael Augoustidis of Domukur Architects, the firm that designed the project. "It's very energy-efficient."
Although he's not ready to declare victory yet, Gardon says the historic building, which was built in 1917 as the Arts Center, is nearing the goal line and ready to score.
Source: Scott Garson
Writer: Lee Chilcote
"Everybody thinks it's wonderful, great… The trick is getting the first one in," he says. "I have enough letters of intent out there that I'm confident it's only a matter of time."
Garson says the demand is there for flexible, ready-to-grow office space geared towards biomedical, research and technology companies, which is why he decided to undertake the project. He points out that nearby buildings owned by Geis Companies and Cumberland Development are almost completely full.
So far, Garson has completed the project without a bank loan, using partner equity and a $720,000 loan from the city, $2.5 million in tax increment financing, federal and state historic tax credits, and a $1 million State of Ohio job ready sites grant. Garson expects to secure bank financing in the near future for tenant build-outs.
The building's unique features include a new interior with a historic waffle slab ceiling, window wells that allow plenty of natural light, copious backup power, fiber-optic connectivity, and the right mechanicals in place for laboratory space. The building will be certified LEED Silver, saving tenants 20 percent on utility costs. Finally, it has views of downtown, free parking and HealthLine access.
"We went through a recycling program with the materials and our landscaping uses stormwater management strategies," says Michael Augoustidis of Domukur Architects, the firm that designed the project. "It's very energy-efficient."
Although he's not ready to declare victory yet, Gardon says the historic building, which was built in 1917 as the Arts Center, is nearing the goal line and ready to score.
Source: Scott Garson
Writer: Lee Chilcote
Cleveland Clinic Innovations has launched a spinoff company, Shield Biotech, out of the Lerner Research Institute. Led by Vincent Tuohy, the company is developing a vaccine for breast cancer.
The vaccine uses the body’s own immune system to fight off and kill cancerous tumors. Tuohy, who serves as Shield’s chief science officer, has been working on this theory for the past 11 years.
The next step is to secure FDA approval for human clinical trials, probably within the next two years. Researchers found that a single vaccination could prevent breast tumors from occurring in mice genetically bred to develop breast cancer, while also inhibiting the growth of already existing breast tumors. The research was originally published in Nature Medicine in 2010.
“It works in animals,” says Tuohy. “It’s safe and very effective. We’d like to see women live longer without tumors, not women live longer with tumors.”
Tuohy sees the vaccine as particularly effective in breast cancers that are aggressive and tend to recur. “Triple-negative breast cancer has a higher recurrence rate than other forms of breast cancer and is insensitive to current forms of adjuvant therapy,” he says. “It’s the predominant form of breast cancer that occurs, for example, in women with BRCA1 mutations. “
Tuohy sees potential in eventually immunizing against prostrate and ovarian cancers as well.
Source: Vincent Tuohy
Writer: Karin Connelly
The vaccine uses the body’s own immune system to fight off and kill cancerous tumors. Tuohy, who serves as Shield’s chief science officer, has been working on this theory for the past 11 years.
The next step is to secure FDA approval for human clinical trials, probably within the next two years. Researchers found that a single vaccination could prevent breast tumors from occurring in mice genetically bred to develop breast cancer, while also inhibiting the growth of already existing breast tumors. The research was originally published in Nature Medicine in 2010.
“It works in animals,” says Tuohy. “It’s safe and very effective. We’d like to see women live longer without tumors, not women live longer with tumors.”
Tuohy sees the vaccine as particularly effective in breast cancers that are aggressive and tend to recur. “Triple-negative breast cancer has a higher recurrence rate than other forms of breast cancer and is insensitive to current forms of adjuvant therapy,” he says. “It’s the predominant form of breast cancer that occurs, for example, in women with BRCA1 mutations. “
Tuohy sees potential in eventually immunizing against prostrate and ovarian cancers as well.
Source: Vincent Tuohy
Writer: Karin Connelly
Kelli Hanley Potts has lived in Denver and Albuquerque, where she got involved in the slow food movement, replaced her front lawn with a vegetable garden, and worked for some of those cities' top chefs. When she got the urge to move back home to Cleveland, she knew she wanted to do something food-related.
That's when she stumbled upon a business idea. Despite the rise of the local food movement, most people had no idea how to cook kale, make jam or preserve food. She asked 18 female friends if they knew how to make a pie from scratch, and only two said yes.
Additionally, many people in the local farming movement have trouble explaining and marketing their products to customers, who are largely unfamiliar with them, she explains.
There are no cooking schools in Cleveland that did what she wanted to do -- connect people back to the land and back to their grandmothers' kitchens by teaching them the age-old skills of home economics -- so she decided to create one.
"I didn't want to watch a chef in front of me and drink wine," says Hanley Potts. "I wanted to learn something. I wanted to reconnect people to the lineage of the table, help them build their own table culture."
She recently launched the Agrarian Collective, an earth-to-table lifestyle school. Her mobile cooking school is offering classes this fall that cover topics like roasting your own coffee, fermented and cultured foods, and discovering local apples, among others. She'll be teaching students how to make the perfect pesto at this weekend's Cleveland Flea.
She was aided by a $5,000 low-interest loan from Bad Girl Ventures, which enabled her to purchase supplies and begin reaching out to chefs and farmers as partners.
"This is like home ec, but not quite as official and nerdy," she says. "It's about reconnecting people. All these things we once learned and were taught, they're missing. We're teaching people the 'how' of home."
Source: Kelli Hanley Potts
Writer: Lee Chilcote
That's when she stumbled upon a business idea. Despite the rise of the local food movement, most people had no idea how to cook kale, make jam or preserve food. She asked 18 female friends if they knew how to make a pie from scratch, and only two said yes.
Additionally, many people in the local farming movement have trouble explaining and marketing their products to customers, who are largely unfamiliar with them, she explains.
There are no cooking schools in Cleveland that did what she wanted to do -- connect people back to the land and back to their grandmothers' kitchens by teaching them the age-old skills of home economics -- so she decided to create one.
"I didn't want to watch a chef in front of me and drink wine," says Hanley Potts. "I wanted to learn something. I wanted to reconnect people to the lineage of the table, help them build their own table culture."
She recently launched the Agrarian Collective, an earth-to-table lifestyle school. Her mobile cooking school is offering classes this fall that cover topics like roasting your own coffee, fermented and cultured foods, and discovering local apples, among others. She'll be teaching students how to make the perfect pesto at this weekend's Cleveland Flea.
She was aided by a $5,000 low-interest loan from Bad Girl Ventures, which enabled her to purchase supplies and begin reaching out to chefs and farmers as partners.
"This is like home ec, but not quite as official and nerdy," she says. "It's about reconnecting people. All these things we once learned and were taught, they're missing. We're teaching people the 'how' of home."
Source: Kelli Hanley Potts
Writer: Lee Chilcote
As millenials, empty nesters and other demographic groups flock to downtowns across Ohio, business improvement districts -- or BIDs -- are playing an important role in ensuring that these areas are clean and safe and that residents, office workers and property owners have the amenities they need to thrive.
A business improvement district is a defined area in which property owners pay an additional tax in order to fund projects and services that enhance the area. Downtown Cleveland has a BID, and the organization provides basic "clean and safe" services, organizes events and markets downtown to prospective residents, visitors and businesses.
This week, Downtown Cleveland Alliance, which manages the downtown BID, organized the first all-Ohio BID conference, bringing together BID leaders from across the state to network and learn about issues they share in common.
"It came from the idea that there's not a unifying organization or conference for BIDs," says Anna Beyerle with DCA. "We can learn a lot from other BIDs across Ohio. The idea was to get in the same room and throw out ideas and best practices."
Topics included food truck legislation, downtown transportation, farmers markets, placemaking, and office and retail recruitment strategies.
Participants also enjoyed several tours of downtown Cleveland and the surrounding area and had a chance to learn from Cleveland's redevelopment.
Beyerle says the conference will help BIDs, such as the one in downtown Cleveland, to become more effective. "We're up for renewal in a couple years, and we're looking at how we can improve."
Source: Anna Beyerle
Writer: Lee Chilcote
A business improvement district is a defined area in which property owners pay an additional tax in order to fund projects and services that enhance the area. Downtown Cleveland has a BID, and the organization provides basic "clean and safe" services, organizes events and markets downtown to prospective residents, visitors and businesses.
This week, Downtown Cleveland Alliance, which manages the downtown BID, organized the first all-Ohio BID conference, bringing together BID leaders from across the state to network and learn about issues they share in common.
"It came from the idea that there's not a unifying organization or conference for BIDs," says Anna Beyerle with DCA. "We can learn a lot from other BIDs across Ohio. The idea was to get in the same room and throw out ideas and best practices."
Topics included food truck legislation, downtown transportation, farmers markets, placemaking, and office and retail recruitment strategies.
Participants also enjoyed several tours of downtown Cleveland and the surrounding area and had a chance to learn from Cleveland's redevelopment.
Beyerle says the conference will help BIDs, such as the one in downtown Cleveland, to become more effective. "We're up for renewal in a couple years, and we're looking at how we can improve."
Source: Anna Beyerle
Writer: Lee Chilcote
clinic's cosgrove aims to improve health of residents and city
In a lengthy Forbes feature titled "City Surgeon: Can The Cleveland Clinic Save Its Hometown?" writer Matthew Herper reports on Delos “Toby” Cosgrove's tenure at the Cleveland Clinic and his efforts to leverage healthcare to improve the Clinic's neighborhood and the region's economy.
"The rough old neighborhood is a distant memory, replaced by a gleaming testament to modern medicine stretching out over 46 buildings and covering 167 acres. Protected by a dedicated 141-trooper force of state police, there is a conference center, a fancy hotel and a farmers’ market. Over Cosgrove’s tenure the clinic’s revenues have nearly doubled to $6.2 billion."
But Cosgrove's biggest brainstorm was to build a "giant mall for hospital buyers."
"Think about the things that go into a hospital. Shades, televisions, chairs, tables, wall coverings, all the medical gear, the operating tables, you name it,” Cosgrove is quoted in the piece.
"What is emerging is an Epcot Center for med tech. GE Healthcare, Siemens, Philips Health Care and Cardinal Health are among the 22 confirmed tenants in the soon-to-be-completed center. Next door, Bennett has already booked conventions that will bring 89,395 attendees this year and 100,400 next. By the end of 2016, he says, bookings should be enough to pay back the $465 million it took to construct both buildings."
“It will begin to influence the city as it comes back and make it a destination medical city,” Cosgrove predicts.
Read the rest of the article here.
"The rough old neighborhood is a distant memory, replaced by a gleaming testament to modern medicine stretching out over 46 buildings and covering 167 acres. Protected by a dedicated 141-trooper force of state police, there is a conference center, a fancy hotel and a farmers’ market. Over Cosgrove’s tenure the clinic’s revenues have nearly doubled to $6.2 billion."
But Cosgrove's biggest brainstorm was to build a "giant mall for hospital buyers."
"Think about the things that go into a hospital. Shades, televisions, chairs, tables, wall coverings, all the medical gear, the operating tables, you name it,” Cosgrove is quoted in the piece.
"What is emerging is an Epcot Center for med tech. GE Healthcare, Siemens, Philips Health Care and Cardinal Health are among the 22 confirmed tenants in the soon-to-be-completed center. Next door, Bennett has already booked conventions that will bring 89,395 attendees this year and 100,400 next. By the end of 2016, he says, bookings should be enough to pay back the $465 million it took to construct both buildings."
“It will begin to influence the city as it comes back and make it a destination medical city,” Cosgrove predicts.
Read the rest of the article here.
Nine local biomedical companies were named to this year’s Inc. 5000 list, a tally of the fastest growing companies in the country in terms of jobs and revenue. Inc. measured revenue growth from 2009 to 2012.
The list represents companies across every industry, but the number of area biomed companies named to the list is encouraging to the growing biomed industry in Cleveland.
“It’s a very exciting time right now in Northeast Ohio for the biomedical industry," says Aram Nerpouni, president and CEO of BioEnterprise. “It’s a little bit of validation here that you can really grow and thrive in the region.”
Nerpouni says the list reflects a combination of young startups and more established companies. Cleveland-based Bravo Wellness, founded in 2008, ranked 888 overall on the Inc. 5000 list. The company, which provides health insurance consulting, ranked 68 on the top 100 health companies. Bravo added 94 jobs in the past three years.
Twinsburg-based CoverMyMeds ranked at the top of the Ohio healthcare companies at 96 on the Inc. 5000 list. The company added 32 employees in the past three years.
“You’re beginning to see a lot of young companies looking at the area,” says Nerpouni of the Health Tech Corridor, located between University Circle and the Campus District. “We should start seeing more and more activity.” Already, 500,000 square feet have opened up in the area in the last six months, with 80 percent occupancy.
In 2012, 43 Cleveland biomedical companies raised $227 million in equity funding.
Source: Aram Nerpouni
Writer: Karin Connelly
The list represents companies across every industry, but the number of area biomed companies named to the list is encouraging to the growing biomed industry in Cleveland.
“It’s a very exciting time right now in Northeast Ohio for the biomedical industry," says Aram Nerpouni, president and CEO of BioEnterprise. “It’s a little bit of validation here that you can really grow and thrive in the region.”
Nerpouni says the list reflects a combination of young startups and more established companies. Cleveland-based Bravo Wellness, founded in 2008, ranked 888 overall on the Inc. 5000 list. The company, which provides health insurance consulting, ranked 68 on the top 100 health companies. Bravo added 94 jobs in the past three years.
Twinsburg-based CoverMyMeds ranked at the top of the Ohio healthcare companies at 96 on the Inc. 5000 list. The company added 32 employees in the past three years.
“You’re beginning to see a lot of young companies looking at the area,” says Nerpouni of the Health Tech Corridor, located between University Circle and the Campus District. “We should start seeing more and more activity.” Already, 500,000 square feet have opened up in the area in the last six months, with 80 percent occupancy.
In 2012, 43 Cleveland biomedical companies raised $227 million in equity funding.
Source: Aram Nerpouni
Writer: Karin Connelly
Jason Tilk, a Cleveland Institute of Art graduate, designs award-winning medical innovations for Nottingham Spirk, the Cleveland-based business innovation firm. By night, the wildly creative trailblazer performs Vaudeville-style shows with his wife that incorporate songs, jokes and "bad magic."
Next week, Lutheran Metropolitan Ministry (LMM) celebrates the grand opening of its new headquarters in a former textile manufacturing shop at E. 45th Street and Superior Avenue. The redeveloped office not only makes LMM more efficient, sustainable and accessible, it also contains a 2,400-square-foot central kitchen and 6,000-square-foot metal shop that allows the group to advance its social enterprise branch.
Michael Sering, Vice President at LMM, says that the organization is able to churn out hundreds of bike racks a year using the new metal shop. Recently, LMM inked a contract with the Cleveland Clinic to build and install an additional 136 racks. LMM employs individuals from 2100 Lakeside, a men's shelter, to make the racks.
The new, spacious central kitchen will allow LMM to continue its work to employ individuals reentering society after time in prison. LMM already prepares about 1,500 meals per day for area homeless shelters and other social service facilities.
LMM is preparing to break ground on a new community garden adjacent to 2100 Lakeside. Sering hopes to build a custom fence for the garden in the metal shop.
LMM's new administrative headquarters are named after Richard Sering, Michael Sering's father and LMM's former director. Richard Sering died of cancer 10 years ago.
Source: Michael Sering
Writer: Lee Chilcote
Michael Sering, Vice President at LMM, says that the organization is able to churn out hundreds of bike racks a year using the new metal shop. Recently, LMM inked a contract with the Cleveland Clinic to build and install an additional 136 racks. LMM employs individuals from 2100 Lakeside, a men's shelter, to make the racks.
The new, spacious central kitchen will allow LMM to continue its work to employ individuals reentering society after time in prison. LMM already prepares about 1,500 meals per day for area homeless shelters and other social service facilities.
LMM is preparing to break ground on a new community garden adjacent to 2100 Lakeside. Sering hopes to build a custom fence for the garden in the metal shop.
LMM's new administrative headquarters are named after Richard Sering, Michael Sering's father and LMM's former director. Richard Sering died of cancer 10 years ago.
Source: Michael Sering
Writer: Lee Chilcote
Leslie Friend will be the first person to tell you that what she does is dangerous, but it's also a real thrill and great workout. She teaches aerial silks classes, best known as the acrobatic art form of Cirque du Soleil, at two different locations in Cleveland, the Studio Cleveland and Sokol Greater Cleveland.
"It utilizes every aspect of the body: core strength, balance and flexibility," says Friend. "Most importantly for most people, it builds confidence. A lot of people have a fear of doing stuff off the ground, and this builds up their confidence."
Aerial silks athletes climb and perform acrobatic maneuvers on nylon fabrics that are rigged to the ceiling. Friend starts class participants low to the ground, and as they advance in ability, she allows them to climb higher into the air to perform tricks. She's never had an accident, although participants sometimes do get tangled.
"We've had to build a tower of mats to reach them," she says. "We always tell people, 'If you're ever in doubt, back yourself out, lower yourself to the floor.'"
In Friend's classes, silks climbers can reach heights of up to 20 feet in the air. They entwine themselves in the silks to perform spins and hang upside down.
Although aerial silks classes are growing in popularity, there still are very few places in Ohio where you can even try it. Friend's classes have become so popular this year that she's introduced software on her websites allowing people to sign up in advance.
Classes typically cost between $15 and $20, with discounts available for five-class packages. All of the classes are open to beginners as well as more advanced aerial silks athletes.
Source: Leslie Friend
Writer: Lee Chilcote
"It utilizes every aspect of the body: core strength, balance and flexibility," says Friend. "Most importantly for most people, it builds confidence. A lot of people have a fear of doing stuff off the ground, and this builds up their confidence."
Aerial silks athletes climb and perform acrobatic maneuvers on nylon fabrics that are rigged to the ceiling. Friend starts class participants low to the ground, and as they advance in ability, she allows them to climb higher into the air to perform tricks. She's never had an accident, although participants sometimes do get tangled.
"We've had to build a tower of mats to reach them," she says. "We always tell people, 'If you're ever in doubt, back yourself out, lower yourself to the floor.'"
In Friend's classes, silks climbers can reach heights of up to 20 feet in the air. They entwine themselves in the silks to perform spins and hang upside down.
Although aerial silks classes are growing in popularity, there still are very few places in Ohio where you can even try it. Friend's classes have become so popular this year that she's introduced software on her websites allowing people to sign up in advance.
Classes typically cost between $15 and $20, with discounts available for five-class packages. All of the classes are open to beginners as well as more advanced aerial silks athletes.
Source: Leslie Friend
Writer: Lee Chilcote
BioMotiv, a pharmaceutical accelerator formed last year to speed early-stage medical developments to market, announced last week that the company has now raised $46 million in total capital, adding Nationwide Mutual Insurance and several individual investors to original investors University Hospitals and the Harrington Family Foundation.
Additionally, BioMotiv announced Monday that the company has formed a multi-million dollar, seven-year partnership with San Diego-based Torrey Pines Investment, a specialty life sciences investor. “We have now raised $46 million in total funding,” says BioMotiv CEO Baiju Shah. “This further investment partnership will expand capital available for projects by up to $20 million through co-investment by Torrey Pines.”
Shah says BioMotiv has just started to identify projects of interest and started development work on those projects. The partnership with Torrey Pines expands the scope of BioMotiv’s work. “We’re pleased with the prospective partnership,” says Shah. “It’s been in the works for about nine months now. In the partnership we will jointly invest in projects -- one in the cancer area and two projects in neuroscience.”
Shah says BioMotiv is also working on developments in several other fronts, including anti-inflammatory and blindness. “Our mission is to accelerate breakthrough discoveries in medications that actually benefit patients,” says Shah. “These are medications that are in the early stages of clinical validation -- phase one or two patient studies. Once we prove it works in patients, then we’re in a place to partner with agencies to get it to market.”
Cleveland is the hot spot for companies like BioMotiv, Shah says, making it attractive to companies like Torrey Pines. “Cleveland is an incredible medical innovation environment,” he says. “We are on the global radar for medical innovations, so it’s easy for us to find partners. In many ways, healthcare is our defining industry as a community.”
BioMotiv currently has eight employees, but Shah says they will be adding staff as the company continues to grow.
Source: Baiju Shah
Writer: Karin Connelly
Additionally, BioMotiv announced Monday that the company has formed a multi-million dollar, seven-year partnership with San Diego-based Torrey Pines Investment, a specialty life sciences investor. “We have now raised $46 million in total funding,” says BioMotiv CEO Baiju Shah. “This further investment partnership will expand capital available for projects by up to $20 million through co-investment by Torrey Pines.”
Shah says BioMotiv has just started to identify projects of interest and started development work on those projects. The partnership with Torrey Pines expands the scope of BioMotiv’s work. “We’re pleased with the prospective partnership,” says Shah. “It’s been in the works for about nine months now. In the partnership we will jointly invest in projects -- one in the cancer area and two projects in neuroscience.”
Shah says BioMotiv is also working on developments in several other fronts, including anti-inflammatory and blindness. “Our mission is to accelerate breakthrough discoveries in medications that actually benefit patients,” says Shah. “These are medications that are in the early stages of clinical validation -- phase one or two patient studies. Once we prove it works in patients, then we’re in a place to partner with agencies to get it to market.”
Cleveland is the hot spot for companies like BioMotiv, Shah says, making it attractive to companies like Torrey Pines. “Cleveland is an incredible medical innovation environment,” he says. “We are on the global radar for medical innovations, so it’s easy for us to find partners. In many ways, healthcare is our defining industry as a community.”
BioMotiv currently has eight employees, but Shah says they will be adding staff as the company continues to grow.
Source: Baiju Shah
Writer: Karin Connelly
There are now dozens of high-performing charter and public schools in the City of Cleveland. Yet a culture of school choice still is not the norm in many Cleveland neighborhoods, and as many as 60 percent of city families have not yet chosen a school to attend.
With the deadline looming on August 19th, those families that do not proactively choose a school will be enrolled in their neighborhood school, which may or may not be the best option depending on how the school is ranked on State of Ohio report cards.
Perhaps most startling is the fact that many high-performing schools in the city have empty seats waiting to be filled even as kids are enrolled in failing schools.
That's why the Transformation Alliance has launched an unprecedented campaign to "promote one common goal of driving enrollment to high-performing schools," says Megan O'Bryan, a nonprofit veteran who is its new Executive Director.
"The ultimate goal of the Transformation Alliance is to ensure that every child in Cleveland attends an excellent school and every neighborhood has a portfolio of high-quality school choices," says O'Bryan. "Our goal is to fill empty seats in the high-performing schools, and over time, drive demand to these good choices. In the marketplace, that demand will then naturally drive out low-performers."
Parents can learn more about school ratings at the Right School Right Now site. The group has completed three different mailers to 25,000 households promoting school choice options. Fliers have been passed out through local community groups. Families can also call 211 to learn more about school ratings.
"The goal is to get parents to look at the info and say, 'My child's school is in Academic Watch, but two miles away there's a school rated Excellent. Why?'"
Although the Transformation Alliance and this campaign are so new that they do not yet have formal goals, O'Bryan says the aim is a "cultural shift" that will take time. "I took this job because it’s an opportunity to create that cultural shift. It's very important for every single resident and the region that this shift occurs. It's a matter of equality and social justice. It's about economic success for our region."
Source: Megan O'Bryan
Writer: Lee Chilcote
With the deadline looming on August 19th, those families that do not proactively choose a school will be enrolled in their neighborhood school, which may or may not be the best option depending on how the school is ranked on State of Ohio report cards.
Perhaps most startling is the fact that many high-performing schools in the city have empty seats waiting to be filled even as kids are enrolled in failing schools.
That's why the Transformation Alliance has launched an unprecedented campaign to "promote one common goal of driving enrollment to high-performing schools," says Megan O'Bryan, a nonprofit veteran who is its new Executive Director.
"The ultimate goal of the Transformation Alliance is to ensure that every child in Cleveland attends an excellent school and every neighborhood has a portfolio of high-quality school choices," says O'Bryan. "Our goal is to fill empty seats in the high-performing schools, and over time, drive demand to these good choices. In the marketplace, that demand will then naturally drive out low-performers."
Parents can learn more about school ratings at the Right School Right Now site. The group has completed three different mailers to 25,000 households promoting school choice options. Fliers have been passed out through local community groups. Families can also call 211 to learn more about school ratings.
"The goal is to get parents to look at the info and say, 'My child's school is in Academic Watch, but two miles away there's a school rated Excellent. Why?'"
Although the Transformation Alliance and this campaign are so new that they do not yet have formal goals, O'Bryan says the aim is a "cultural shift" that will take time. "I took this job because it’s an opportunity to create that cultural shift. It's very important for every single resident and the region that this shift occurs. It's a matter of equality and social justice. It's about economic success for our region."
Source: Megan O'Bryan
Writer: Lee Chilcote