Health + Wellness
“What we observed at Juventas in treatments for heart disease, we have observed in wound treatment with the same product,” explains Rahul Aras, SironRX president and CEO. “With SRX100, we accelerate treatment in dermal wounds and prevent scarring. While normal healing occurs in about 21 days, healing occurred 20 to 30 percent faster with significantly less scarring with our product.”
The product will be used in post-surgical incisions, chronic diabetic ulcers and burns. SironRX’s goal is to develop a cost-effective interactive wound therapy that can be topically administered with the potential to significantly improve function of the damaged tissue.
“It’s a great concept, applying concepts that make the body heal,” Aras says. “Repairing injured organs to heal themselves, I think that’s pretty exciting.”
As clinical trials continue, SironRX will be ramping up a full-time management teams, including a full-time CEO, and operational staff.
Source: Rahul Aras
Writer: Karin Connelly
Nominated innovations were required to: Have significant potential for short-term clinical impact; Have a high probability of success; Be on the market or close to being introduced; Have sufficient data available to support its nomination.
Among them are:
Genetically modified mosquitoes to reduce disease threat.
Novel diabetes therapy that represents a paradigm shift in diabetes treatment.
Harnessing big data to improve heath care.
Active bionic prosthesis with microprocessors and computer chips that can rival the functionality provided by biological limbs.
Implantable devices to treat complex brain aneurysms.
Next-generation gene sequencing to get to the root cause of serious illness.
Medical apps for mobile devices.
Concussion management system for athletes that provide patient-specific guidance about when athletes can return to play without risk of further harm.
CT Scans for early detection of lung cancer.
Read the full report here.
The gift establishes the Barbara and A. Malachi Mixon III Institute Chair in Ophthalmology. Daniel F. Martin, MD, Chairman of Cole Eye Institute, is being honored as the first physician to hold the newly established chair. As chair holder, Dr. Martin will continue his research initiatives to better understand eye diseases and to pioneer new treatments.
“We are grateful for the generosity of the Mixon family,” Dr. Martin said. “This gift will provide resources to advance our research efforts, including increasing involvement in clinical trials and serving as a catalyst for cutting-edge research programs.”
Read the rest of the good news here.
“Anybody who acquires an image during a bio-science event, it’s a subjective process for anyone who looks at that image,” says ImageIQ CEO Tim Kulbago. “We build custom solutions to get quantitative scientific data.”
Kulbago likens ImageIQ’s capabilities to a police officer’s speed radar gun. Without it, people in the medical industry are just estimating their findings. The company has three areas of expertise: pharmaceutical, medical devices and research.
While the company still is in its infancy, the folks behind the research at Image IQ have years of experience. “We feel like we’re on the leading edge of actual medical imaging,” says Kulbago. “Our team has been doing this for over 10 years. Now we’re taking the idea of this service to market.”
ImageIQ has developed working relationships with NASA, MIT and, most recently, Anderson Orthopaedic Research Institute (AORI) to enhance the ongoing joint replacement research. ImageIQ and AORI will apply state-of-the-art 3D imaging analytics to improve the assessment of the structural integrity and performance of various biomaterials in orthopedic implant wear studies.
ImageIQ has grown from four people on staff to eight in just eight months. “Now were at a point where word is starting to get out,” says Kulbago. They are prepared to grow as the company grows. Kulbago plans to host a webinar in November, “60 in 60: Speed Dating for Imaging Analytics,” which has already produced significant interest.
Source: Tim Kulbago
Writer: Karin Connelly
"Working Mother readers want flexibility and they want it now," say the editors of the magazine. "In survey after survey, working moms rank flexible work arrangements as the most desired benefit they seek, even higher than compensation or paid days off."
The Working Mother 100 Best Companies are judged on answers to 650 questions, including data on the access and usage of flexible work arrangements, parental leave, childcare, health and wellness support and the advancement of women to all levels of management.
Jennifer Owens, Editorial Director of Working Mother said, "The reason flexibility is so important to working moms is that they want to do their best at home and in the office. Flexible work arrangements allow moms both. The Working Mother Best Companies want to win the war for talent and productivity -- especially in a down economy -- and they have figured out how to make flex work.”
See the full list here.
Patients with PAD have in the past had little hope for treatment, let alone a cure – until Theravasc started researching the effect of a drug used to treat cyanide poisoning. The drug, called TV1001, showed promise in the trial, which included 12 diabetic patients.
“People with PAD can’t walk and are in pain, and there’s nothing doctors can do,” explains Tony Giordano, Theravasc president and CEO. “This drug causes new blood vessels to grow in that leg, and only that leg. In animal studies it was doing exactly what we wanted it to do.”
The next step is a IIA trial followed by a third trial, to test the effects of giving the drug chronically. Giordano says if all goes well, TV1001 would hit the market in 2015. He thinks about his father-in-law and a 84-year old Shreveport, LA woman who was ranked seven on the tennis circuit – both affected by PAD – when he thinks about the positive possibilities of the drug.
“I think there’s a high likelihood that we’re going to see success in humans,” Giordano says. “I think this is going to work, and I know this is not going to hurt them. It will give them an opportunity to lead a better life and start walking again. I’m excited about that.”
Source: Tony Giordano
Writer: Karin Connelly
The Cleveland-based company, working with the Cleveland Clinic’s Glickman Urological Institute, CWRU, Toshiba Medical Systems and Canon, received $1 million for the development of specialty MRI coils for imaging donor kidneys before transplant to determine viability.
Currently, potentially viable kidneys are sometimes rejected for transplant, or there are complications after transplant. This technology will improve the chances of success as well as reduce the number of kidneys that are thrown away.
“The program will result in a turnkey system of equipment, analysis software and clinical protocols which will be marketed to transplant centers on a worldwide basis,” says John L. Patrick, chief technical marketing officer for QED.
“Recipients of kidneys from deceased donors would benefit in several ways: Higher confidence level that the transplanted kidney can be viable and better knowledge of its condition; increase of transplanted kidneys by reducing the number of viable kidneys discarded will increase the number of patients able to benefit from transplantation.”
Patrick says the technology should be on the market in less than two years, depending on how clinical trials go. QED expects to begin hiring additional people for development of the technology in the next few months.
“In the proposal we stated that 38 jobs would be created at QED within 3 years,” says Patrick. “In fact, we believe that number to be quite conservative.”
Source: John L. Patrick
Writer: Karin Connelly
“[Cleveland Bio Fund] will provide both capital and know-how for device companies looking to expand their products into China. It is a unique boutique style investment strategy needed for that market,” explains Eddy Zai, CEO of CbF
Executives are traveling to Cleveland this week to meet local officials, tour the Health Tech Corridor, and meet with companies that could take advantage of this unique business model.
Cleveland Mayor Frank G. Jackson welcomes the investment in Cleveland from China.
"Investments in the City of Cleveland are good, whether they are made locally or by foreign investors. We welcome the opportunity to partner with the Cleveland Bio Fund as it will better connect Cleveland to the global economy," said Mayor Frank Jackson.
Read the rest here.
Wright says the proliferation of local gardens is helping local residents to grow and eat healthier food, save money on food expenses, reuse and beautify vacant land, improve community health outcomes and potentially earn money by selling locally grown produce at the Coit Road Farmers Market.
"We're definitely making an impact," says Wright, citing the presence of nine community gardens in the city. "East Cleveland has an unusually high concentration of gardens for a small city. When you look at Cuyahoga County as a whole, it actually has the second highest number of gardens."
Three years ago, OSU Extension, the Cuyahoga County Board of Health, and the Cuyahoga County Planning Commission applied for and were awarded a grant from the Center for Disease Control. The resulting program, Creating Healthy Communities, helps to address public health issues in East Cleveland and Euclid by providing better food choices and encouraging healthier lifestyles.
"We chose East Cleveland because it has low access to fresh foods and high rates of chronic, preventable diseases like heart disease, diabetes and obesity," says Wright. "We want to help people to become more self-reliant."
East Cleveland was also selected because of its Coit Road Farmers Market, a local institution that is not frequented often enough by local residents, says Wright. One of the goals of Creating Healthy Communities is to turn that trend around.
In recent years, the farmers market has been encouraging local residents to grow and sell their produce at the market. This fruitful partnership is helping to reengage local residents with this fresh food venue. "This is about promoting the market that's right there in the community," says Wright.
Source: Nicole Wright
Writer: Lee Chilcote
Just ask Margaret Bilyeau, owner of the newly opened Maggie's Vegan Bakery, who boasts of her vegan "chocolate" cupcakes with "cream cheese" icing: "You need to come try them -- they're wonderful."
That shouldn't be too hard; she offers free samples to customers who stop in her store, located at 1830 W. 25th Street in Ohio City's ever-expanding Market District.
Bilyeau first started baking professionally in 1994. She sold her goods at farmers markets and the now-closed Food Co-op on Coventry Road in Cleveland Heights. Advised by a Co-op employee that she should start baking vegan because few others were serving that market, Bilyeau started doing just that.
But first she had to learn what being vegan actually means. "I said to him, 'What's that? How do you do it?'" she says. "He told me, 'You have to figure it out.' At the time, not very many people were doing it. It's a much bigger market now."
Although Bilyeau prepares her vegan baked goods strictly sans dairy, her customers aren't limited to hardcore vegans or vegetarians. Increasingly, they are also heart patients or elderly people that can't eat dairy for health reasons, or people who aren't consuming dairy products because of religious reasons.
Bilyeau also makes gluten-free baked goods to serve another growing market -- people with Celiac Disease who are allergic to wheat, rye and barley. "It's hard to find fresh gluten-free bread," she says. "It's flying off of the shelves."
Her ultimate goal is to ramp up her distribution business and ensure that more restaurants in Cleveland carry vegan and gluten-free desserts and other baked goods.
Bilyeau chose Ohio City because she shops at the West Side Market and saw new businesses opening up in the area.
"We're right between the new Mexican restaurant, Orale, and Johnnyville Slugger," she says. "I love being here."
Source: Margaret Bilyeau
Writer: Lee Chilcote
One of the research projects, led by Ray Muzic, associate professor of radiology, oncology and biomedical engineering at CWRU, combines PET and MRI technologies for more accurate mammograms. “It benefits women with early detection of breast cancer with low-coast, low-risk mammograms,” he says. “It provides spot-on imaging and reduces false positives.”
The new technology uses glucose to detect tumor growth. “A tumor that’s growing rapidly uses a lot of glucose,” explains Muzic. “We’re trying to look at the functional differences, not the structural differences. It could eliminate the need for needle biopsies."
The other project, led by David Wilson, professor of biomedical engineering and radiology at CWRU, develops a cardiac perfusion imaging, which will measure blood flow in the heart to determine if there is reduced blood flow in the heart following a heart attack.
Not only will these technologies help in the prevention and treatment of disease, they will bring jobs to the area.
“Phillips will sell more scanners, which will create more jobs and revenue in Northeast Ohio, all while improving women’s health,” says Muzic. He expects production to being in three to five years.
Source: Raymond Muzic
Writer: Karin Connelly
The company, which has grown from eight to 80 employees in two years, just completed an $18.4 million Series B financing round with Excel Venture Management and HealthCare Ventures, both out of Boston.
The investment will allow Cleveland HeartLab to expand -- both in employees and market acceptance. In addition to its current offerings, the company plans to introduce additional diagnostic tests in 2012. "The goal is to eliminate the threat of vascular inflammation," he says.
"The funding allows the company to double in size again," says Jake Orville, president and CEO. "And we've just committed to moving off [the Clinic's] campus to the Health Tech Corridor."
Orville predicts the company will double again in the next two years, adding positions in management, sales, marketing, and research and development. He attributes his company's growth to a talented, dedicated staff.
"We have the gift of really good novel technology," he says. "Combine that with really good people and a really good business plan."
Source: Jake Orville
Writer: Karin Connelly
Last January, a group of religious and community leaders got together under one common goal: To make Cleveland a better place to work and live. The Greater Cleveland Congregations (GCC) was born. A united front of 40 religious and community organizations began collecting input on what the city needed to do to improve.
“Between January and March we asked participating organizations, ‘What makes life better for you and your family in Cleveland?’” explains Ari Lipman, GCC lead organizer. Four hundred participants came up with five areas to focus on: education, healthcare, jobs, criminal justice and sustainable food.
GCC officially kicked off its mission in June with a founding assembly. More than 2,000 Clevelanders attended to put their heads together and come up with a collective bargaining of sorts to improve the living standard.
“Each of the five areas has started action teams,” notes Lipman. “For jobs, we’re looking at job training -- jobs that exist that you can support a family on and primarily on jobs creation.”
The GCC is part of the Industrial Areas Foundation, the nation’s first and largest network of multi-faith coalitions. Lipman cites success stories in other chapters around the nation as proof that the same kind of team power can work in Cleveland.
"In Washington state, the group figured out a way of expanding the number of green jobs,” says Lipman. “They signed up people to get their houses winterized, got 1,000 people signed up and created over 100 jobs.”
While the group is still in the research phase, they plan to unveil their action plan this winter. “By 2012 we’re going to have interesting and exciting ideas,” says Lipman. “We’re going to need some people to help implement them.”
Source: Ari Lipman
Writer: Karin Connelly
A vacant Euclid Avenue storefront has now become a community hub thanks to East 4th Yoga, a new studio that offers free yoga classes and aims to enhance the sense of community downtown.
The studio, which launched last month, offers complimentary, donation-based classes on Saturday mornings at 10 in the former Bang and the Clatter Theatre space at 244 Euclid. While geared towards downtown residents, anyone is welcome to attend. Organizer Tammy Oliver, an East 4th resident, says the studio creates a community gathering space and promotes downtown living.
“There aren’t many opportunities for this kind of gathering space downtown,” says Oliver. “The more opportunities we provide people to live, work and play, the more likely they’ll be to live downtown. We’re trying to create a neighborhood.”
To fund the program, Oliver secured a sponsorship from Oasis Health Care. Additionally, MRN Ltd. has donated the former theatre space, and yoga instructors from across the city volunteer their time. Finally, MVP Valet offers free valet parking for individuals traveling from other parts of the city.
Oliver, who organized the yoga classes as a volunteer, is also the leasing agent for East 4th Street. She says the idea was generated through discussions with friends who can’t afford to take regular yoga classes, and through brainstorming with downtown residents about other amenities that are needed downtown.
“It’s not enough to provide nice living spaces, we need places to shop, hang out and meet our neighbors,” says Oliver. She adds that MRN Ltd. is actively working on plans to recruit additional retailers to the East 4th and Euclid Avenue area.
The funds raised from class donations will be used to purchase equipment such as yoga mats and blocks that will be donated to the Cleveland Metropolitan School District (CMSD). Oliver is hoping to work with a group of yoga instructors and CMSD to create a yoga program that is geared towards urban youth.
“We can use yoga to enrich and bring peace to young people’s lives,” she says.
Source: Tammy Oliver
Writer: Lee Chilcote
A team of researchers has developed an artificial lung that uses regular air, not pure oxygen, and is portable, marking a huge step forward for people with acute and chronic lung disease. The research is a result of collaboration between CWRU and the Louis Stokes Cleveland VA Medical Center.
"The most significant finding is that we have demonstrated a small scale, prototype artificial lung," says Joseph A. Potkay, research assistant professor in CWRU's department of electrical engineering and computer science. "It represents a major leap forward toward a self-contained, portable or implantable device that would use ambient air, rather than oxygen cylinders, and would thus give patients full mobility."
Current artificial lung systems require heavy tanks of oxygen, limiting patients' portability -- and they can be used only on patients at rest. Also, the lifetime of the system is measured in days. This new prototype is much smaller in size -- equivalent to a natural lung.
"These results prove that constructing a device with features similar in size to those found in the natural lung can result in large improvements in efficiency over current alternatives, thereby enabling portable devices," says Potkay. "This technology will be used in portable heart lung machines and portable systems for the treatment of acute and chronic lung disease or as a bridge to transplant."
Potkay and his team began developing the lung in early 2008 and will begin animal testing in two years. Human trials should begin in 10 years. The research was funded by the U.S. Department of Veterans Affairs. Lung disease affects over 200 million people worldwide.
Source: Joseph A. Potkay
Writer: Karin Connelly
On August 30th, dozens of new fruit trees will be planted near W. 85th and Franklin Boulevard on vacant land that was recently home to dilapidated row houses.
According to Jeanette Toms, Special Programs Coordinator with the nonprofit Cudell Improvement Inc., the neighborhood secured the gift after winning enough votes in an online competition to place among the top five entries in the country. Facing stiff competition from entries around the country, Cudell solicited votes from as far away as Florida, Italy and Portugal in order to land the win.
"My dad lives in Florida, so when he came to visit, we asked him to help spread the word among his friends," says Toms. "You could vote once per day."
The competition is sponsored by Edy's Fruit Bars and the Fruit Tree Planting Foundation, an international foundation that is "dedicated to planting fruit-bearing trees in places that best benefit the community -- public schools, city parks and low-income neighborhoods," according to the program's website.
Cudell Improvement plans to install an irrigation system to ensure the trees are properly watered. In three to five years, when the trees begin bearing fruit, the group plans to give the fruit away to neighborhood residents and food pantries.
Source: Jeanette Toms
Writer: Lee Chilcote
Arteriocyte, a leading clinical-stage biotechnology company with offices in Cleveland and Hopkinton, Mass., has been awarded a $1 million grant by the Ohio Department of Development's Third Frontier Commission. The company, which develops proprietary stem cell and tissue engineering based therapies, will use the grant for the development and commercialization of hematopoietic stem cell expansion for clinical applications.
The move is part of the Ohio Third Frontier Biomedical Program to accelerate the company's Good Manufacturing Practices (GMP) of its NANEX technology for clinical use under the product name HemaEx.
"The technology takes a small amount of stem cells and gets a large amount of stem cells," explains Adam Sorkin, Arteriocyte's director of research and development. "We are converting our existing process that is suitable for research to a process that is suitable for use in humans.".
Arteriocyte's therapies help find cures for chronic heart disease and peripheral artery disease, among other diseases.
The company, which was founded in 2004 as a spin-off out of CWRU, has seen rapid growth in the past couple of years, going from four employees to 80. The expansion will create between 15 and 20 jobs in the production facility.
Source: Adam Sorkin
Writer: Karin Connelly
"The surprise darling of the Community Food Security Coalition conference last May was a little-known city councilman from Cleveland," Hannah Wallace writes for Faster Times. "He spoke fervently about his city, a city of flourishing community gardens, backyard bee hives and chicken coops, a city where all farmers markets accept food stamps, where schools get discounts for sourcing local food, and where both trans-fats and smoking on playgrounds are banned. His name? Joe Cimperman."
In this lengthy Q and A, Cimperman discusses some of the efforts that are helping Cleveland become a "food justice utopia," and a model for other cities to emulate.
Cimperman explains how in 2007, Cleveland became the first city to pass an urban farm zoning law, leading to an explosion of community gardens. He says that by 2020, the goal is to have a community garden within five blocks of every Cleveland resident.
He also mentions progressive city programs like urban chickens and bees, farmers markets accepting food stamps, and shoring up food deserts with fresh produce.
"Community gardens just make us a nicer city," Cimperman says in the article. "They make us share more, pay more attention to each others' kids, understand each others' cultures more. There are just so many ancillary benefits to community gardens -- we can't imagine."
Digest the rest here.